Radiochemistry Home Research Interests Research Group Contact Us
Patents Related to the Research
Vessella R.L., Wilbur D.S., Buhler K.R., and Lange P.H. (2001) Experimental Models and Methods in Antibody Targeting of Renal Cell Carcinoma. Meth. Mol. Med. 53, 217-242.
Tan P.H., Chu V., Stray J., Hamlin D.K., Pettit D., Wilbur D.S., Vessella R.L., and Stayton P.S. (1998) Engineering the Isoelectric Point of a Renal Cell Carcinoma Targeted Antibody Greatly Enhances scFv Solubility. ImmunoTechnology 4, 107-114.
Fritzberg A.R. and Wilbur D.S. (1995) Radiolabeling of Antibodies for Targeted Diagnostics. In Targeted Delivery of Imaging Agents. (Torchilin V.P, Ed.), Chapt. 6, pp 83 - 101, CRC Press, Boca Raton, FL.
Wilbur D.S., Stray, J.E., Hamlin, D.K., Curtis, D.K. and Vessella, R.L. (1994) Monoclonal Antibody Fab' Fragment Cross-Linking Using Equilibrium Transfer Alkylation Reagents. Strategy for Site-Specific Conjugation of Diagnostic and Therapeutic Agents with F(ab')2 Fragments. Bioconjugate Chem. 5, 220-235.
Murray J.L., Mujoo K., Wilmanns C., Mansfield P., Wilbur D.S., and Rosenblum M.G.: (1991) Variables Influencing Tumor Uptake of Antimelanoma Monoclonal Antibodies Radioiodinated Using the Para-Iodophenyl (PIP) Technique. J. Nuc. Med 32, 279-287.
Abrams P.G., Fritzberg A.R., Wilbur D.S., Beaumier P.L., Carrasquillo J.A., , Larson S.M., Schroff R.W., Morgan A.C., Eary J.F., and Nelp W.B. (1991) Imaging and Therapy of Metastatic Carcinoma with Radiolabeled Monoclonal Antibodies. In Principles of Cancer Biotherapy, R.K. Oldham, Ed., Chapter 16, pp 471-492, Marcel Dekker, Inc., New York.
Badger C.C., Wilbur D.S., Hadley S.W., Fritzberg A.R. and Bernstein I.D. (1990) Biodistribution of Para-Iodobenzoyl (PIP) Labeled Antibodies in a Murine Lymphoma Model. Appl. Radiat. Isot., B, Nucl. Med. Biol. 17, 381-387.
Eary J.F., Schroff R.W., Abrams P.G., Fritzberg A.R., Morgan A.C., Kasina S., Reno J.M., Srinivasan A., Woodhouse C.S., Wilbur D.S., Natale R.B., Collins C., Stehlin J.S., Mitchell M. and Nelp W.B. (1989) Successful Imaging of Malignant Melanoma with Technetium-99m Labeled Monoclonal Antibodies. J. Nucl. Med. 30, 25-32.
Abrams P., Schroff R., Fritzberg A., Morgan A.C., Wilbur D.S., Srinivasan A., Reno J., Sivam G., Kasina S., Vanderheyden J.L., Beaumier P., Salk D. and Fer M. (1989) Controlled Labeling of Monoclonal Antibodies for Imaging Metastatic Cancer: A Prelude to Therapy. In Human Tumor Antigens and Specific Tumor Therapy. Metzer R.S. and Mitchell M.S., Eds., pp 191-197, Alan R. Liss, Inc. New York.
Pretargeting Reagents and Methods
Press O.W., Corcoran M., Subbiah K., Hamlin D., Wilbur D.S., Johnson T., Theodore L., Yau E., Mallett R., Meyer D., and Axworthy D. (2001) A Comparative Evaluation of Conventional and Pretargeted Radioimmunotherapy of CD20-expressing Lymphoma Xenografts. Blood 98, 2535-2543.
Wilbur D.S., Pathare P.M., Hamlin D.K., Stayton P.S., To R., Klumb L.A., Buhler K.R., and Vessella R.L. (1999) Development of New Biotin / Streptavidin Reagents for Pretargeting. Biomolecular Eng. 16, 113-118.
Wilbur D.S., Hamlin D.K., Pathare P.M., Buhler K.R., and Vessella R.L. (2000) Evaluation of Succinylated Streptavidin as the Radionuclide Carrier in Antibody Pretargeting of Prostate Cancer. In Isotope Production and Applications in the 21st Century, (N.R. Stevenson, Editor), Proceedings of the Third International Conference on Isotopes, Vancouver, B.C. Sept. 6-10, 1999, pp 167-169, World Scientific Publishing Co., Inc., River Edge, NJ.
Wilbur D.S., Hamlin D.K., Vessella R.L., Stray J.E., Buhler K.R., Stayton P., Klumb L., Pathare P.M., and Weerawarna S.A. (1996) Antibody Fragments in Tumor Pretargeting. Evaluation of Biotinylated Fab’ Co-localization with Recombinant Streptavidin and Avidin. Bioconjugate Chem. 7, 689-702.
Wilbur D.S., Hamlin D.K., Chyan M.-K., Kegley B.B., and Pathare P.M. (2001) Biotin Reagents for Antibody Pretargeting. 5. Additional Studies of Biotin Conjugate Design to Provide Biotinidase Stability. Bioconjugate Chem. 12, 616-623.
Wilbur D.S., Chyan M.-K., Pathare P.M., Hamlin D.K., Frownfelter M.B., and Kegley B.B. (2000) Biotin Reagents for Antibody Pretargeting 4. Selection of Biotin Conjugates for In Vivo Application Based on Their Dissociation Rate from Avidin and Streptavidin. Bioconjugate Chem. 11, 569-583.
Wilbur D.S., Pathare P.M., Hamlin D.K., Frownfelter M.B., Kegley B.B., Leung W.-Y., and Gee K.R. (2000) Evaluation of Biotin-Dye Conjugates for Use in an HPLC Assay to Assess Relative Binding of Biotin Derivatives with Avidin and Streptavidin. Bioconjugate Chem. 11, 584-598.
Hamlin D.K., Wilbur D.S., Pathare P.M., Subramaniam D.S., Corcoran M., and Press O.W. (2000) Evaluation of Antibody Biotinylation Reagents For Application to Targeted Radiotherapy. Isotope Production and Applications in the 21st Century (N.R. Stevenson, Editor) Proceedings of the Third International Conference on Isotopes, Vancouver, B.C. Sept. 6-10, 1999, pp 353-355, World Scientific Publishing Co., Inc., River Edge, NJ.
Wilbur D.S., Pathare P.M., Hamlin D.K., Stayton P.S., Klumb L.A., Tan P., To R., Vessella R.L., and Buhler K.R. (1998) Development of Biotin Trimers as Reagents to Increase (Radio)nuclide Localization in Antibody Pretargeting. In Synthesis and Applications of Isotopically Labeled Compounds 1997, J.R. Heys and D.G. Melillo, Editors, pp295-298, John Wiley & Sons, Ltd, Chichester, UK.
Wilbur D.S., Pathare P.M., Hamlin D.K., Buhler K.R., and Vessella R.L. (1998) Biotin reagents for Antibody Pretargeting. 3. Synthesis, Radioiodination and Evaluation of Biotinylated Starburst Dendrimers. Bioconjugate Chemistry 9, 813-825.
Wilbur D.S., Hamlin D.K., Pathare P.M., and Weerawarna S.A. (1997) Biotin Reagents for Antibody Pretargeting. 2. Synthesis and In Vitro Evaluation of Biotin Dimers and Trimers for Cross-Linking of Streptavidin. Bioconjugate Chem. 8, 819-832.
Wilbur D.S., Hamlin D.K., Pathare P.M., and Weerawarna S.A. (1997) Biotin Reagents For Antibody Pretargeting. Synthesis, Radioiodination and In Vitro Evaluation of Water Soluble, Biotinidase Resistant Biotin Derivatives. Bioconjugate Chem. 8, 572-584.
Stayton P.S., Hoffman A.S., Murthy N., Lackey C., Cheung C., Tan P., Klumb L.A., Chilkolti A., Wilbur D.S., and Press O.W. (2000) Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics. J. Controlled Release 65, 203-220.
Wilbur D.S., Hamlin D.K., Buhler K.R., Pathare P.M., Vessella R.L., Stayton P.S., and To R. (1998) Streptavidin in Antibody Pretargeting. 2. Evaluation of Methods to Decrease Localization of Streptavidin to Kidney while Retaining its Tumor Binding Capacity. Bioconjugate Chem. 9, 322-330.
Wilbur D.S., Stayton P.S., To R., Klumb L.A., Hamlin D.K., Vessella R.L., Buhler K.R., and Stray J.E. (1998) Streptavidin in Antibody Pretargeting. Comparison of a Recombinant Streptavidin with Two Streptavidin Mutant Proteins and Two Commercially Available Streptavidin Proteins. Bioconjugate Chem. 9, 100-107.
Radiohalogenation Reagents and Methods
Speranza M., Shuie C.Y., Wolf A.P., Wilbur D.S. and Angelini G. (1985) Electrophilic Radiofluorination of Aryltrimethylsilanes as a General Route to F-18 Labelled Arylfluorides. J. Fluorine Chem. 30, 97-107.
Speranza M., Shiue C.Y., Wolf A.P., Wilbur D.S. and Angelini G. (1984) Regiospecific Radiofluorination of Arylpentafluorosilicates as a General Route to F-18-Labelled Arylfluorides. J. Chem. Soc. Chem. Commun. 1448-1449.
Wilbur D.S., Hamlin D.K., Buhler K.R., Srivastava R.R., Stray J.E., Daniel J. and Vessella R.L. (1995) Comparison of In Vivo Distributions of Simple Radioiodinated Borane and Carborane Cage Molecules. Proceedings of the Ninth International Symposium on Radiopharmacology, Ann Arbor Michigan, June 7-10. Quart. Rev. Nucl. Med. 39, 51-52.
Wilbur D.S., Hamlin D.K. and Srivastava R.R. (1994) Radioiodinations of nido-Carboranes. Potential Hydrophilic Pendant Groups for Radiohalogenation of Biological Molecules. J. labelled Compds. Radiopharm. 35, 199-201.
Wilbur D.S., Hamlin D.K., Srivastava R.R., and Burns H.D. (1993) Synthesis and Radioiodination of N-Boc-p-(tri-n-butylstannyl)-L-phenylalanine Tetrafluoro-phenyl Ester: Preparation of a Radiolabeled Phenylalanine Derivative for Peptide Synthesis. Bioconjugate Chem. 4, 574-580.
Wilbur D.S. (1992) Radiohalogenation of Proteins: An Overview of Radionuclides, Labeling Methods and Reagents for Conjugate Labeling. Bioconjugate Chem. 3, 433-470.
Hylarides M.D., Wilbur D.S., Reed M.W., Hadley S.W., Schroeder J.R. and Grant L.M. (1991) Preparation and In Vivo Evaluation of an [125I]Iodophenethylmaleimide Antibody Conjugate. Bioconjugate Chem. 2, 435-440.
Wilbur D.S., Hadley S.W., Grant L.M. and Hylarides M.D. (1991) Radioiodinated Iodobenzoyl Conjugates of a Monoclonal Antibody Fab Fragment. In Vivo Comparisons with Chloramine-T Labeled Fab. Bioconjugate Chem. 2, 111-116.
Hadley S.W. and Wilbur D.S. (1990) Evaluation of Iodovinyl Antibody Conjugates: Comparison with a Para-Iodobenzoyl Conjugate and Direct Radioiodination. Bioconjugate Chem. 1, 154-161.
Hylarides M.D., Wilbur D.S., Hadley S.H. and Fritzberg A.R. (1989) Synthesis and Iodination of Methyl 4-Tri-n-Butylstannylbenzoate, 4-Carbomethoxyphenyl Mercuric Chloride and 4-Carbomethoxyphenyl Boronic Acid. J. Organometallic Chem. 367, 259-265.
Wilbur D.S., Hadley S.W., Hylarides M.D., Abrams P.G., Beaumier P.L., Morgan A.C., Reno J. and Fritzberg A.R. (1989) Development of a Stable Radioiodinating Reagent to Label Monoclonal Antibodies For Radiotherapy of Cancer. J. Nucl. Med. 30, 216-226.
Wilbur D.S., Jones D.S., and Fritzberg A.R. (1986) Synthesis and Radioiodinations of Some Aryltin Compounds for Radiolabeling of Monoclonal Antibodies. Sixth International Symposium on Radiopharmaceutical Chemistry. Boston, Mass. June 1986. J. Labelled Compds. Radiopharm. 23, 1304-1306.
Wilbur D.S. and Hylarides M.D. (1991) Radiolabeling of A Monoclonal Antibody with N-Succinimidyl Para-[77Br]Bromobenzoate. Int. J. Radiat. Appl. Instrum. [A], Nucl. Med. Biol. 18, 363-365.
Hanson R.N., El-Wakil, Murphy F. and Wilbur D.S. (1989) Synthesis and Evaluation of 82Br and 77Br Labeled (17,20)-21-bromo-19-norprena-1,3,5(10),20-tetraene-3,17-diol. J. Labelled Compds. Radiopharm. 27, 615-627.
Hylarides M.D., Leon A.A., Mettler F.A. and Wilbur D.S. (1985) Radiolabeling of B- and C-Ring of Estradiol Using No-Carrier-Added Bromine-77. J. Labelled Compds. Radiopharm. 22, 443-450.
Hylarides M.D., Buksa P.L., Mettler F.A. and Wilbur D.S. (1985) Radiobromination of the 1-position of Estradiol Using No-Carrier-Added Bromine-77. J. Labelled Compds. Radiopharm. 22, 437-441.
Hylarides M.D., Leon A.A., Mettler F.A., and Wilbur D.S. (1984) Synthesis of 1-Bromoestradiol. J. Org. Chem. 49, 2744-2745.
Wilbur D.S., Garcia S.R., Adam M.J. and Ruth T.J. (1984) An Evaluation of the Introduction of Stable Nuclides of Bromine into High Specific Activity Radiobrominations. J. Labelled Compds. Radiopharm. 21, 767-779.
Wilbur D.S. and Svitra Z.V. (1984) Electrophilic Radiobrominations of Hippuric Acid: An Example of the Utility of Aryltrimethylsilane Intermediates. J. Label. Compds. Radiopharm. 21, 415-428.
Wilbur D.S. and Svitra Z.V. (1983) Organopentafluorosilicates. Reagents for Rapid and Efficient Incorporation of No-Carrier-Added Radiobromine and Radioiodine. J. Labelled Compds. Radiopharm. 20, 619-626.
Wilbur D.S., Stone W.E. and Anderson K.W. (1983) Regiospecific Incorporation of Bromine and Iodine into Phenols Using Trimethylsilylphenol Derivatives. J. Org. Chem. 48, 1542-1544.
Wilbur D.S., Anderson K.W., Stone W.E. and O'Brien H.A., Jr. (1982) Radiohalogenation of Non-activated Aromatic Compounds Via Aryltrimethylsilyl Intermediates. J. Labelled Compds. Radiopharm. 19, 1171-1187.
Wilbur D.S. and O'Brien H.A., Jr. (1982) A-Ring Bromination of Estradiol and 17-Ethynylestradiol with N-Chlorosuccinimide and Bromide Ion. J. Org. Chem. 47, 359-362.
Wilbur D.S. and Anderson K.W. (1982) Bromine Chloride from N-Chlorosuccinimide Oxidation of Bromide Ion. Electrophilic Addition Reactions in Protic and Aprotic Solvents. J. Org. Chem. 47, 358-359.
Wilbur D.S., Bentley G.E. and O'Brien H.A., Jr. (1981) A Rapid Synthesis of A-Ring Bromine-77-Labeled Estrogens with High Specific Activity. J. Label. Compds. Radiopharm. 18, 1693-1701.
Wilbur D.S. (2001) Overcoming the Obstacles to Clinical Evaluation of Astatine-211 Radiopharmaceuticals. [Invited Commentary] J. Nucl. Med. 42, 1516-1518.
Wilbur D.S., Vessella R.L., Stray J.E., Goffe D.K., Blouke K.A., and Atcher R.W. (1993) Preparation and Evaluation of Para-[211At]Astatobenzoyl Labeled Anti-Renal Cell Carcinoma Antibody A6H F(ab')2. In Vivo Distribution Comparison with Para-[125I]Iodobenzoyl Labeled A6H F(ab')2. Nucl. Med. Biol. 20, 917-927.
Hadley S.W., Wilbur D.S., Gray M.A. and Atcher R.W. (1991) Astatine-211 Labeling of an Anti-Melanoma Antibody and its' Fab Fragment using N-Succinimidyl Para-[211At]Astato-benzoate: Comparisons In Vivo with the Para-[125I]Iodobenzoyl Conjugate. Bioconjugate Chem. 2, 171-179.
Wilbur D.S., Hadley S.W., Hines J.J., and Atcher R.W. (1990) Assessment of Dry Distillation Methods for Improving Protein Labeling Yields with Astatine-211. Eighth International Symposium of Radiopharmaceutical Chemistry, Princeton, New Jersey, June 24-25, J. Labelled Compds. Radiopharm. 30, 214-215.
Wilbur D.S. (1990) Potential Use of Alpha Emitting Radionuclides in the Treatment of Cancer. Antibodies, Immunoconj. Radiopharm. 4, 85-97.
Wilbur D.S., Hylarides M.D. and Fritzberg A.R. (1989) Reactions of Organometallic Compounds with Astatine-211. Application to Protein Labeling. Radiochemica Acta 47, 137-142.
Bray L.A., Tingey J.M., DesChane J.R., Egorov O.B., Tenforde T.S., Wilbur D.S., Hamlin D.K., Pathare P.M., and Finn R. (2000) Development of a Unique Bismuth (Bi-213) Automated Generator for Use in Cancer Therapy. Industrial & Chemical Engineering Research 39, 3189-3194.
Pathare P.M., Hamlin D.K., Wilbur D.S., Brechbiel M.W., and Bray L.A. (1998) Synthesis and Radiolabeling of a Biotin-CHX-B Chelate for Bi-213. J. Labelled Compds Radiopharm. 41, 595-603.
Laramore G.E., Griffin T.W., Risler R., Wootton P., Stelzer K.J., and Wilbur D.S. (1997) Boron neutron Capture (BNC): A mechanism for enhancing tumor cell kill in fast neutron radiotherapy. Proceedings of the International Conference on Neutrons in Research and Industry. SPIE 2867, 23-26.
Laramore G.E., Wootton P., Wilbur D.S., Risler R., Phillips M., Buchholz T.A., Livesey J.C. and Griffin T.W. (1996) BNCT as an Adjuvant to Fast Neutron Radiotherapy for Selected Tumor Systems. In Cancer Neutron Therapy, Mishima, Ed, pp 777-782, Plenum Press, New York.42. Laramore G.E., Risler R., Griffin T.W., Wootton P. and Wilbur D.S. (1996) Fast Neutron radiotherapy and boron neutron capture therapy: application to a human melanoma test system. Bull. Cancer Radiother. 83, 191S-197S.
Bucholz T.A., Laramore G.E., Wootton P., Livesey J.C., Wilbur D.S., Risler R., Phillips M., Jacky J. and Griffin T.W. (1994) Enhancement of Fast Neutron Beams with Boron Neutron Capture Therapy: A Mechanism for achieving a selective, concomitant tumor boost. Acta Oncologica 33, 307-313.
Wilbur, D.S., Hamlin, D.K., Livesey J.C., Srivastava, R.R., Laramore, G.E. and Griffin, T.W. (1994) Synthesis of nido-1,2-Carboranyl Derivatives of 2-Nitroimidazole. Int. J. Appl. Radiat. Isot. 21, 601-611.
Laramore G.E., Wootton P., Livesey J.C., Wilbur D.S., Risler R., Phillips M., Jacky J., Bucholz T.A., Griffin T.W., Brossard S. (1994) Boron Neutron Capture Therapy: A Mechanism for Achieving a Concomitant Tumor Boost in Fast Neutron Therapy. Int. J. Radiat. Oncol. Biol. Phys. 28, 1135-1142.
Wilbur D.S., Hamlin D.H., Laramore G.E. and Griffin, T.W. (1993) Preparation of meta-Carborane Derivatives by Thermal Rearrangement in a Small Scale Laboratory Apparatus. In Advances in Neutron Capture Therapy (Soloway A.H., Barth R.F. and Carpenter D.E., Editors), pp 319-323, Plenum Press, New York.
Livesey J.C., Wiens L.W., Wilbur D.S. and Laramore G.E. (1993) Hypoxia-Selective Cellular Toxicity of Carboranyl Nitroimidazole. In Advances in Neutron Capture Therapy (Soloway A.H., Barth R.F. and Carpenter D.E., Editors), pp 315-318, Plenum Press, New York.
Wilbur D.S., Hamlin D.K., Srivastava R.R., Laramore G.E. and Griffin T.W. (1993) Synthesis and Evaluation of Amine Reactive Carboranyl Derivatives for Application to Boron-10 Containing Polymers. In Advances in Neutron Capture Therapy (Soloway A.H., Barth R.F. and Carpenter D.E., Editors), pp 333-337, Plenum Press, New York.
Wilbur D.S., Hamlin D.K., Livesey J.C., Srivastava R.R., Laramore G.E. and Griffin, T.W. (1993) Preparation of meta-Carboranylpropyl-2-nitroimidazole Derivatives for Application to BNCT. In Advances in Neutron Capture Therapy (Soloway A.H., Barth R.F. and Carpenter D.E., Editors), pp 309-313, Plenum Press, New York.
Laramore G.E., Livesey J.C., Wootton P., Wilbur D.S., Jacky J., Risler R. and Vessella, R. (1992) Boron neutron capture therapy: a means of increasing the effectiveness of fast neutron radiotherapy. In Proceedings of the 9th International Congress of Radiation Research, Vol. II, W.C. Dewey, M. Edington, R.J.M. Fry, E.J. Hall, and G.F. Whitmore, Eds., pp 617-622, Academic Press, San Diego.
Wilbur D.S., Pathare P.M., Hamlin D.K., Rothenberg S.P. and Quadros E.V. (1999) Radioiodination of Cyanocobalamin Conjugates Containing Hydrophilic Linkers: Preparation of a Radioiodinated Cyanocobalamin Monomer and Two Dimers, and Assessment of Their Binding with Transcobalamin II. Bioconjugate Chemistry 10, 912-920.
McLean G.R., Pathare P.M., Wilbur D.S., Morgan A.C., Schrader J.W., and Ziltener H.J. (1997) Synthetic Derivatives of Cobalamin: An Analysis of the Effects on Leukemic Cell Growth in vitro. Cancer Res. 57, 4015-4022.
Pathare P.M., Wilbur D.S., Hamlin D.K., Heusser S., Quadros E.V., McLoughlin P., and Morgan A.C. (1997) Synthesis of Cobalamin Dimers Using Isophthalate Cross-Linking of Corrin Ring Carboxylates and Evaluation of Their Binding to Transcobalamin II. Bioconjugate Chem. 8, 161-172.
Wilbur D.S., Hamlin D.K., Pathare P.M., Heusser S., Vessella R.L., Buhler K.R., Stray J.E., Daniel J., Quadros E.V., McLoughlin P., and Morgan A.C. (1996) Synthesis and nca-Radioiodination of Arylstannylcobalamin Conjugates. Evaluation of Aryliodocobalamin Conjugate Binding to Transcobalamin II and Biodistribution in Mice. Bioconjugate Chem. 7, 461-474.
Pathare P.M., Wilbur D.S., Heusser S., Quadros E.V., McLoughlin P., and Morgan A.C. (1996) Synthesis of Cobalamin-Biotin Conjugates That Vary in the Position of Cobalamin Coupling. Evaluation of Cobalamin Derivative Binding to Transcobalamin II. Bioconjugate Chem. 7, 217-232.
Reed M. W., Panyutin I.G., Hamlin D., Lucas D.D., and Wilbur D.S. (1997) Synthesis of 125I Labeled Oligonucleotides from Tributylstannylbenzamide Conjugates. Bioconjugate Chem. 8, 238-243.
Srivastava R.R., Hamlin D.K., and Wilbur D.S. (1996) Synthesis of Highly Iodinated Icosahedral Mono- and Dicarbon Carboranes. J. Org. Chem. 61, 9041-9044.
Fritzberg A.R., Abrams P.G., Beaumier P.L., Kasina S., Morgan A.C., Rao T.N., Reno J.M., Sanderson J.A., Srinivasan A., Wilbur D.S. and Vanderheyden J.L. (1988) Specific and Stable Labeling of Antibodies with Technetium-99m Using a Diamide Dimercaptide (N2S2) Chelating Agent. Proc. Natl. Acad. Sci., USA, 85, 4025-4029.
Grunbaum Z., Freauff S.J., Krohn K.A., Wilbur D.S., Magee S. and Rasey J.S. (1987) Synthesis and Characterization of Congeners of Misonidazole for Imaging Hypoxia. J. Nucl. Med. 28, 68-75.
Wilbur D.S. (1986) Development of No-Carrier-Added Radiotracers with the Aid of Radio-HPLC. In Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry. Wieland D.M., Tobes M.C., and Mangner T.J., Eds., Springer-Verlag.
Croeba R.C. (1982) [Br-77]-17a-Bromoestradiol In Vivo and In Vitro Characterization of an Estrogen Receptor Radiotracer. Int. J. Nucl. Med. Biol. 9, 245-250.
Moore H.W. and Wilbur D.S. (1980) Cyanoketenes. Mechanism of tert-Butylcyanoketene Cycloaddition to Aldo- and Ketoketenes. J. Org. Chem. 45, 4482-4491.
Wilbur D.S. and Moore H.W. (1978) Cyanoketenes. Mechanism of tert-Butylcyanoketene Cycloaddition to Methyl- and Ketoketenes. J. Amer. Chem. Soc. 100, 6523-6525.
D.S. Wilbur and S.W. Hadley: Vinyl Substituted Radiohalogen Conjugates for Protein Labeling. Patent Number 4,870,188; Issued Sept. 26, 1989.
D.S. Wilbur and S.W. Hadley: Vinyl Substituted Radiohalogen and Methods of Use Conjugates. Patent Number 4,876,081; Issued Oct. 24, 1989.
J.M. Reno, B.J. Bottino, and D.S. Wilbur: Radionuclide Antibody Coupling. Patent Number 4,877,868; Issued Oct. 31, 1989.
D.S. Wilbur, A.R. Fritzberg, and D.S. Jones: Radiohalogenated Proteins. Patent Number 4,885,153; Issued Dec. 5, 1989.
A.R. Fritzberg, S. Kasina, A. Srinivasan, and D.S. Wilbur: Metal Radionuclide Labeled Proteins for Diagnosis and Therapy. Patent Number 4,897,255; Issued Jan. 30, 1990.
A.R. Fritzberg, S. Kasina, A. Srinivasan, D.S. Wilbur: Metal Radionuclide Labeled Proteins for Diagnosis and Therapy. Patent Number 5,037,630; Issued Aug. 6, 1991.
D.S. Wilbur and A.R. Fritzberg: Radiohalogenated small molecules for protein labeling. Patent Number 5,045,303; Issued Sept. 3, 1991.
D.S. Wilbur: Modified Cellular Substrates Used As Linkers For Increased Cell Retention of Diagnostic and Therapeutic Agents. Patent Number 5,057,301; Issued Oct. 15, 1991.
A.R. Fritzberg, D.S. Wilbur, A. Srinivasan, and D. W. Wester: Minimal derivatization of proteins. Patent Number 5,059,541; Issued Oct. 22, 1991.
D.S. Wilbur and S.W. Hadley: Process for Isolation and Radiolabeling of Pharmaceuticals with Isotopes of Astatine. Patent Number 5,102,651; Issued April 7, 1992.
A.R. Fritzberg, S. Kasina, A. Srinivasan, and D.S. Wilbur: Method of Producing Metal Radionuclide Labeled Proteins for Diagnosis and Therapy. Patent Number 5,120,526; Issued June 9, 1992.
A.R. Fritzberg, S. Kasina, a. Srinivasan, and D.S. Wilbur: Metal Radionuclide Labeled Proteins for Diagnosis and Therapy. Patent Number 5,175,343; Issued December 29, 1992.
D.S. Wilbur and S.W. Hadley: Vinyl substituted radiohalogen conjugates for protein labeling. Patent Number 5,200,169; Issued April 6, 1993.
D.S. Wilbur and A.R. Fritzberg: Radiohalogenated small molecules for protein labeling. Patent Number 5,213,787; Issued May 25, 1993.
A.R. Fritzberg, S. Kasina, A. Srinivasan, and D.S. Wilbur: Metal Radionuclide labeled proteins for diagnosis and therapy. Patent Number 5,242,679; Issued Sept. 7, 1993.
D.S. Wilbur: Iodinated Borane Cage Molecules as X-Ray Contrast Media. Patent Number 5,489,673; Issued February 6, 1996.
D.S. Wilbur and A.R. Fritzberg: Radiohalogenated small molecules for protein labeling. Patent Number 5,609,848; Issued March 11, 1997.
D.S. Wilbur: Iodinated Borane Cage Molecules as X-Ray Contrast Media. Patent Number 5,679,322; Issued October 21, 1997.
D. S. Wilbur, P.M. Pathare, and A.C. Morgan Jr.: Biotinylated Cobalamins. Patent Number 5,739,287; Issued April 14, 1998.
A.C. Morgan, D.S. Wilbur, and P.M. Pathare: Vitamin B12 Receptor Modulating Agents and Methods Related Thereto. April 24, 1997, WO97/14711, US Patent Number 5,840,712; Issued November 24, 1998.
A.C. Morgan and D.S. Wilbur: Receptor Modulating Agents, US Patent Number 5,840,880; Issued November 24, 1998.
AC. Morgan and D.S. Wilbur: Methods of receptor modulation and uses thereof. US Patent Number 5,869,465; Issued February 9, 1999.
A.C. Morgan, D.S. Wilbur, and P.M. Pathare: Water soluble vitamin B12 receptor modulating agents and methods related thereto. US Patent Number 6,083,926; Issued July 4, 2000.
D.S. Wilbur and P.M. Pathare: Discrete-Length Polyethylene Glycols. US Patent Number 6,294,697; Issued September 25, 2001.