VA Medical Center/ R151
1660 S Columbian Way
Seattle, WA 98108
Tel.: 206-764-2168
Fax: 206-277-1787
1988-1989: Postdoctoral fellow at the Institute of Genetics, Free University of Berlin
1989 -1996: Postdoctoral fellow in Dr. Mark Groudine's laboratory at the Fred Hutchinson Cancer Research Center (FHCRC) in Seattle
1996-2000: Staff scientist in the Division of Basic Sciences of the FHCRC
2000-present: Acting Assistant Professor, University of Washington
1985: MS degree at the Free University of Berlin
1988: Ph.D. degree "summa cum laude"
Doctoral thesis "Regulation of the Sgs-4 gene expression and interaction of DNA- binding proteins with Sgs-4 upstream sequences". Supervisor: Prof. Dr. Korge, Institute of Genetics, Free University of Berlin
1985-1987: Financial support by a Ph.D. grant from the Senat of Berlin
1989-1991: Postdoctoral fellowship by the Deutsche Forschungsgemeinschaft
1991-1992: Postdoctoral fellowship by the Leukemia Research Foundation, Illinois
1993-1996: Special fellowship by the Leukemia Society of America
1996-2001: Co-investigator of NIH grant CA 54337 (R01)
2001-2005: Research Scholar Grant by the American Cancer Society
Krumm, A., Roth, G.E., Korge, G. (1985). Transformation of salivary gland secretion protein gene Sgs-4 in Drosophila: Stage- and tissue-specific regulation, dosage compensation, and position effect. Proc. Natl. Acad. Sci. USA 82, 5055-5059.
Krumm, A., Hofmann, A., Roth, G., Korge, G. (1985). Regulation of the Larval Secretion Protein Gene Sgs-4 Activity in Drosophila melanogaster. Biol. Chem. Hoppe-Seyler 366, 113-126.
Hofmann, A., Keinhorst, A., Krumm, A., Korge, G. (1987). Regulatory sequences of the Sgs-4 gene of Drosophila melanogaster analyzed by P element mediated transformation. Chromosoma 96, 8-17.
Meulia T., Krumm A., Spencer C., Groudine M. (1992). Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter. Mol. Cell. Biol.12,4590-4600.
Krumm A., Meulia T., Brunvand M., Groudine M. (1992): The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region. Genes & Dev. 6, 2201-2213.
Meulia T., Krumm A., Groudine M. (1993). Distinct properties of c-myc transcriptional elongation are revealed in Xenopus oocytes and mammalian cells and by template titration , 5-6-Dichloro-1-ß-D-Ribofuranosylbenzimidazole (DRB), and promoter mutagenesis. Mol. Cell. Biol. 13,5647-5658.
Krumm A., Meulia T., Groudine M. (1993). Common mechanisms of transcription elongation in eukaryotes. Bioessays 15, 659-665.
Brunvand M., Krumm A., Groudine M. (1993). In vivo footprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T-cells. Nucl. Acids Res. 21, 4824-4829.
Koeberl D.D., Halbert C.L., Krumm A., Miller D. (1995). Sequences within the coding regions of Clotting Factor VIII and CFTR block transcriptional elongation.. Human Gene Therapy 6, 471-481.
Krumm A., Hickey L., Groudine M. (1995). Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation. Genes & Dev. 9, 559-572.
Paranjape S.M., Krumm A., Kadonaga J.T. (1995). HMG17 is a chromatin-specific transcriptional coactivator that increases the efficiency of transcription initiation. Genes & Dev. 9, 1978-1991.
Krumm A. and Groudine, M. (1995). Tumor suppression and transcription elongation: The dire consequences of changing partners. Science 269, 1400-1401.
Gnarra J.R., Zhou S., Merill M.J., Wagner J., Krumm A., Papavassiliou E., Oldfield E.H., Klausner R.D., Linehan MW.M. (1996). Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product. Proc.Natl.Acad.Sci. USA, 93, 10589-10594.
Madisen L., Krumm A., Hebbes T.R., Groudine M. (1998). The immunoglobulin heavy chain LCR increases histone acetylation along linked c-myc genes. Mol. Cell. Biol. 18, 6281-6292.
Krumm A., Madisen L., Yang XJ., Goodman R., Nakatani Y., Groudine M. (1998). Long distance transcriptional enhancement by the histone acetyltransferase PCAF. Proc. Natl. Acad. Sci. USA, 95, 13501-13506.
Wu D.Y., Krumm A., Schubach W. (2000). Promoter-specific targeting of the human SWI/SNF complex by Epstein-Barr Virus Nuclear protein 2. J. Virol., 74, 8893-8903.
Phippen T.M., Sweigart A.L., Moniwa M., Krumm A., Davie J.R., Parkhurst S. (2000).
Drosophila CtBP functions as a context dependent transcriptional co-factor and interferes with both Mad and Groucho transcriptional repression. J. Biol. Chem., 275, 37628-37637.