University of Washington School of Medicine
NW145, Box 356069
1959 N.E. Pacific Street
Seattle, WA 98195
Tel: 206-598-4094 (Office)
Tel: 206-598-6813 (Lab)
Fax: 206-598-6813
E-mail: ygu@u.washington.edu
6/84 B.S. in Biochemistry, East China University of Chemical Technology
Thesis title: Topology of the subunits of QH2:cytochrome c reductase from chicken heart---photolabeling of the hydrophobic domain
Advisor: Yun Li, Ph.D.12/93 Ph.D. in Genetics, Thomas Jefferson University
Thesis title: Molecular genetics of human acute leukemia with t(4;11)(q21;q23)
Advisor: Carlo M. Croce, M.D.Postdoctoral training: 1/94-4/94 Cancer genetics
Kimmel Cancer Institute, Thomas Jefferson University
Advisors: Carlo M. Croce, M.D. & Eli Canaani, Ph.D.4/94-2/01 Molecular immunology
Harvard Medical School
Advisor: Frederick W Alt, Ph.D.
84-87 Research Assistant, Shanghai Center for Clinical Laboratory, China
87-89 Research Assistant, Wistar Institute, Philadelphia
94 Postdoctoral Fellow, Kimmel Cancer Institute, Philadelphia
94-01 Research Fellow, Department of Genetics, Harvard Medical School
97-00 Associate, Howard Hughes Medical Institute, Children's Hospital
01-present Assistant Professor, Department of Radiation Oncology, UW
01-present Adjunct Assistant Professor, Department of Immunology, UW
4/94 Cancer Research Institute Fellow
Agency: Nathan Shock Center of Excellence in the Basic Biology of Aging
Title: Mouse Models for Study of SIR2 Function in Development and Aging
Period: 7/1/01-6/30/02 ($30,000)
Role: PIAgency: NIH (RO1 PI: Nelson Fausto)
Title: Pathogenesis of Hepatocellular Carcinomas
Period: 4/1/02-3/31/07 ($200,000 per year)
Role: Collaborator (5%)
Cancer Biology for Residents (organize, and teach 11 of 23 lectures in Winter and Spring, 2002)
R ONC 499 Undergraduate Research
Consultant: UW Mouse Genomic Center (Director, Warren Ladiges)(01-present)
Reviewer: UW Royalty Research Fund (Spring and Fall, 2001)
1. Li Y, Gu Y & Lin CS. (1986). Topology of the subunits of QH2:cytochrome c reductase from chicken heart--photolabeling of the hydrophobic domain. Acta Biochemica et Biophysica Sinica 18(1), 27-34.
2. Cimino G, Nakamura T, Gu Y, Canaani O, Prasad R, Crist W, Carrol A, Baer M, Bloomfield CD, Nowell PC, Croce CM & Canaani E. (1992). Cloning of ALL-1, the locus involved in leukemias with the t(4:11)(q21:q23), t(9:11)(p22:q23) and t(11:19)(q23:p13) chromosome translocation. Cancer Research 52, 3811-3813.
3. Gu Y, Cimino G, Alder H, Nakamura T, Prasad R, Canaani O, Moir DT, Jones C, Nowell PC, Croce CM & Canaani E. (1992). The (4:11)(q21:q23) chromosome translocations in acute leukemia involve the VDJ recombinase. Proc. Natl. Acad. Sci. USA 89, 10464-10468.
4. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM & Canaani E. (1992). The t(4:11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71, 701-708.
5. Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, Croce CM & Canaani E. (1993). Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc. Natl. Acad. Sci. USA 90, 4631-4635.
6. Ma Q, Alder H, Nelson KK, Chatterjee D, Gu Y, Nakamura T, Canaani E, Croce CM, Siracusa LD & Buchberg AM. (1993). Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. Proc. Natl. Acad. Sci. USA 90, 6350-6354.
7. Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama Y, Miyazaki Y, Croce CM & Canaani E. (1993). Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in AMLs with the t(6;11) chromosome translocation. Cancer Research 53, 5581-5585.
8. Gu Y, Alder H, Nakamura T, Schichman SA, Prasad R, Canaani O, Saito H, Croce CM & Canaani E. (1994). Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia. Cancer Reserach 54, 2327-2330.
9. Schichman SA, Caligiuri MA, Gu Y, Strout MP, Canaani E, Bloomfield CD & Croce CM. (1994). ALL-1 partial duplication in acute leukemia. Proc. Natl. Acad. Sci. USA 91, 6236-6239.
10. Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H, Huebner K, Berger R, Croce CM & Canaani E. (1994). Leucine-zipper dimerization motif encoded by the AF-17 gene fused to ALL-1 (MLL-1) in acute leukemia. Proc. Natl. Acad. Sci. USA 91, 8107-8111.
11. Schichman SA, Caligiuri MA, Strout MP, Carter SL, Gu Y, Canaani E, Bloomfield CD & Croce CM. (1994). ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements. Cancer Research 54, 4277-4280.
12. Prasad R, Yano T, Sorio C, Nakamura T, Rallapalli R, Gu Y, Leshkowitz D, Croce CM & Canaani E. (1995). Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia. Proc. Natl. Acad. Sci. USA 92,12160-12164.
13. Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park S-H, Huebner K & Keen JH (1995). Chromosome localization of human genes for clathrin adaptor polypeptides AP2b and AP50 and the clathrin-binding protein, VCP. Genomics 30, 94-97.
14. Gu Y, Jin S, Gao Y, Weaver DT & Alt FW. (1997). Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc. Natl. Acad. Sci. U.S.A. 94,8076-8081.
15. Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng H-L, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB & Alt FW. (1997). Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7, 653-665.
16. Manis JP, Gu Y, Lansford R, Ferrini R, Davidson L, Rajewsky K & Alt FW. (1998). Ku70 is required for late B cell development: a potential role in Ig heavy chain class switching. J. Exp. Med. 187,2081-2089.
17. Alt FW, Frank K, Sekiguchi J, Gao Y, Gu Y, Chaudhuri J, Rathbun G, Seidl KJ, Weaver D. (1998). General-expressed gene products involved in VDJ recombination and DNA repair. Molecular Immunology 35: (11-12) 681-682.
18. Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW. (1999). Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. Cold Spring Habor Symposia on Quantitative Biology 64: 169-181.
19. Gu Y, Sekihuchi JM, Gao Y, Dikkes P, Frank K, Ferguson DO, Hasty P, Chun J & Alt FW. (2000). Defective embryonic neurogenesis in Ku, but not DNA-PKcs, deficient mice. Proc. Natl. Acad. Sci. U.S.A. 97, 2668-2973.
20. Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S., Rathbun GA, Roberts TM, Swat W, Segal RA & Gu Y (2000). Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc. Natl. Acad. Sci. U.S.A. 97, 3336-3341.
21. Sekiguchi JM, Ferguson DO, Chen H-T, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, & Alt FW. (2001). Genetic interaction between Atm and the non-homologous end-joining factors in genomic stability and development. Proc. Natl. Acad. Sci. U.S.A. 98, 3243-3248.
22. Ferguson DO, Sekiguchi JM, Frank K, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA & Alt FW (2001). The interplay between non homologous end joining and cell cycle checkpoint factors in development, genomic stability and tumorigenesis. Cold Spring Habor Symposia on Quantitative Biology In press.